Lana Condor Ruby Gillman (voice) Toni Collette Agatha Gillman (voice) Annie Murphy Chelsea Van Der Zee (voice) Sam Richardson Brill (voice) Liza Koshy Margo (voice) Will Forte Gordon Lighthouse (voice) Colman Domingo Arthur Gillman (voice) Jaboukie Young-White Connor (voice) Eduardo Franco Trevin (voice) Ramona Young Bliss (voice) Echo Kellum (voice) Nicole Byer (voice) Jane Fonda Grandmamah (voice)