Mark Wahlberg Cade Yeager Anthony Hopkins Sir Edmund Burton Josh Duhamel Col. William Lennox Stanley Tucci Merlin Laura Haddock Vivian Wembly Jerrod Carmichael Jimmy Isabela Merced Izabella Santiago Cabrera Santos Glenn Morshower General Morshower John Turturro Seymour Simmons Tony Hale JPL Engineer Liam Garrigan King Arthur Martin McCreadie Lancelot Rob Witcomb Percival Marcus Fraser Gawain John Hollingworth Tristan Daniel Adegboyega Saebert Benjamin Maurice Webb Hengist Gemma Chan Quintessa Claude Knowlton JPL Director Jacob Zachar Young JPL Engineer Peter Cullen Optimus Prime (voice) Frank Welker Megatron (voice) Omar Sy Hot Rod (voice) Reno Wilson Sqweeks / Mohawk (voice) John DiMaggio Crosshairs / Nitro Zeus (voice) Tom Kenny Wheelie (voice) Mark Ryan Lieutenant / WWI Tank (voice)