Shia LaBeouf Sam Witwicky Josh Duhamel Lennox John Turturro Simmons Tyrese Gibson Epps Rosie Huntington-Whiteley Carly Spencer Frances McDormand Mearing John Malkovich Bruce Brazos Patrick Dempsey Dylan Kevin Dunn Ron Witwicky Julie White Judy Witwicky Ken Jeong Jerry Wang Alan Tudyk Dutch Glenn Morshower General Morshower Lester Speight Eddie Buzz Aldrin Self Bill O'Reilly Self Ravil Isyanov Voshkod Markiss McFadden Lennox Team 'Baby Face' Scott C. Roe Lennox Team 'Nelson' Elya Baskin Cosmonaut Dimitri Peter Cullen Optimus Prime (voice) Leonard Nimoy Sentinel Prime (voice) James Remar Sideswipe (voice) Francesco Quinn Dino (voice) Tom Kenny Wheelie (voice) Reno Wilson Brains (voice) Frank Welker Shockwave / Soundwave / Barricade (voice) John DiMaggio Leadfoot / Target (voice)